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产品编号
1098803
CAS 号
19741-14-1
中文名称
4-[N-(2,4-二氨基-6-蝶啶甲基)-N-甲氨基]苯甲酸半盐酸盐N水
MDL 号
MFCD00075774
分子量
325.33
存储条件
2-8°C
网页展示纯度为入库指导纯度值，各批次间存在一定差异，实际纯度以收货为准
熔点
255 °C
沸点
689.3±65.0 °C at 760 mmHg
闪点
旋光
描述
TPSA
144.14
LogP
0.9188
H_Acceptors
8
H_Donors
3
Rotatable_Bonds
4
[1]. Schofield RC, et al. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:169-75.
[2]. B Nuernberg, et al. Rapid quantitation of methotrexate and its metabolites in human serum, urine and bile, using solid-phase extraction and high-performance liquid chromatography. J Chromatogr. 1989 Feb 24;487(2):476-82.
[3]. D A Cairnes, et al. High-performance liquid chromatographic assay of methotrexate, 7-hydroxymethortrexate, 4-deoxy-4-amino-N10-methylpteroic acid and sulfamethoxazole in serum, urine and cerebrospinal fluid. J Chromatogr. 1982 Aug 13;231(1):103-10.
[4]. Eva Klapkova, et al. The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination. Clin Lab. 2011;57(7-8):599-606.
[5]. J Salamoun, et al. Determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N10-methylpteroic acid in biological fluids by liquid chromatography with fluorimetric detection. J Chromatogr. 1986 May 28;378(1):173-81.
警示图
警示词
Danger
危险申明
H301-H315-H319-H341-H360
警告申明
P264-P270-P280-P302+P352-P330-P362+P364-P405-P501
GHS 编码
GHS06,GHS08
危险类别
6.1
UN 编码
2811
包装等级
Ⅲ
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