Standards; Molecular Biology; Pharmaceutical/API Drug Impurities/Metabolites;
应用
6,7-Dimethoxy-4-(4-nitrophenoxy)quinoline is a related compound of cabozantinib (CAS# 849217-68-1) with potential anticancer activity. It can be used in the preparation of nicotinamide derivatives as Aurora kinase inhibitors, nquinolinyloxyphenylbenzenesulfonamides as AXL kinase inhibitors, N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas as vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitors, and phenoxyquinolines as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase.
参考文献
Lien, V. T., et al.: Monatsh. Chem., 150, 1947 (2019); Xu, Q., et al.: Bioorg. Med. Chem. Lett., 29, 126630 (2019); Qi, B., et al.: Bioorg. Med. Chem., 27, 3825 (2019); Szabadkai, I., et al.: J. Med. Chem., 61, 6277 (2018); Kubo, K., et al.: J. Med. Chem., 48, 1359 (2005); Kubo, K., et al.: Bioorg. Med. Chem., 11, 5117 (2003)
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