Building Blocks; Molecular Biology; Pharmaceutical/API Drug Impurities/Metabolites;
应用
Des-(3,4-dihydrogen-3-oxo) Favipiravir is a building block related to Favipiravir (CAT# F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever. Des-(3,4-dihydrogen-3-oxo) Favipiravir may be useful in the preparation of novel pyrazine derivatives as antiviral agents.
参考文献
Oestereich, L., et al.: Antiviral Res., 105, 17 (2014); Baranovich, T., et al.: J. Virol. 87, 3741 (2013); Chem. and Eng. News p.8, Dec. 1 (2014); Egawa, H., et al.: PCT Int. Appl., 137 pp. (2001)
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