2-DIethylamino-6-hydroxy-4-methylpyrimidine is used in the synthesis of heterocyclic compounds with two heteroatoms, displaying pharmacophoric properties. Also used in the synthesis of dual imhibitors for the HIV-1 caspid and human cyclophilin A enzymes which both play essential roles in HIV-1 assembly and replication.
参考文献
Vel'chinskaya, E. et al.: Chem. Hetero. Comp., 33, 847 (1998); Li, J. et al.: Bioorg. Med. Chem. Lett., 17, 3177 (2009);
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