Diisopropyl Carbonate (Stabilized with Calcium Carbonate)
中文名称
碳酸二异丙酯
分子式
C₇H₁₄O₃
分子量
146.18
Smiles Code
存储条件
4
性状
Colourless Oil
溶解性
Chloroform (Slightly), Ethyl Acetate
类别
Standards; Chiral Molecules; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用
Diisopropyl Carbonate is used in the synthesis of Huperizine A (H826000) a reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
参考文献
Ding, X. et al.: Tetrahedron 68, 6240 (2012); Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986), Ved, H.S., et al.: Neuroreport, 8, 963 (1997)
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