5,5-Dimethylisoxazolidin-3-one is a derivative of Ethyl 3-Methyl-2-butenoate (E925065), which is used in the synthesis of Endothelin-A antagonist ABT-546 used in the preparation of antidepressant Rolipram. Also used in the synthesis of potent inhibitors of human inducible nitric oxide synthases, important enzymes in cellular signaling.
参考文献
Barnes, D. et al.: J. Am. Chem. Soc., 124, 13097 (2002); Hagen, T. et al.: J. Med. Chem., 41, 3675 (1998)
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