3-(4-Fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid is used in the discovery of pyrimidinediones as potential orally bioavailable axl inhibitor. The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance and has been identified as a promising target for anticancer therapeutics.
参考文献
Zhang, H., et al.: J. Med. Chem., 64, 3956 (2021);
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