Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用
3-Hydroxy-1-azabicyclo[2.2.2]octane-3-methanol is used in the preparation of agonists at nicotonic acetylcholine receptors. It is an impurity in the synthesis of Cevimeline (C283500), a novel muscarinic M1 and M3 receptor agonist. Sialagogue.
参考文献
Mullen, G. et al.: J. Med. Chem., 43, 4045 (2000); Masunaga, H., et al.: Eur. J. Pharmacol., 339, 1 (1997); Arisawa, H., et al.: Arzneim.-Forsch., 52, 14 (2002); Yasuda, H., et al.: Clin. Drug Invest., 22, 67 (2002); Ono, M., et al.: Am. J. Ophthalmol., 138, 6 (2004);
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