Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用
5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue of┬аthiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor ╬│ (PPAR╬│). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.
参考文献
Bhanushali, U., et al.: Bioorg. Chem., 67, 139-147 (2016); Chen, Z., et al.: J. Biol. Chem. 287, 23537 (2012); Fukunaga, T., et al.:В J.В Bone Miner. Res., 30, 508 (2015)
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