Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
应用
5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
参考文献
Yamazaki, Y. et al.: Zeitsch. Naturforsch. C: J. Biosci., 65, 49 (2010); Kay, W.W. et al.: Gen. Pharmacol., 8, 201 (1977); Ghebregzabher, M. et al.: J. Chrom. Biomed. Appl., 222, 191 (1981);
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