Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
应用
b-Hydroxyisovaleric Acid is a metabolite of the essential amino acid Leucine and is synthesized in the human body. Studies suggest that b-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated b-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency.
参考文献
Nissen, S., et al.: J. Appl. Physiol., 81, 2095 (1996); Wilson, G.J., et al.: Nutrit. Metab., 5, 1 (2008); Mock, D.M., et al.: Am. J. Clin. Nutrit., 76, 1061 (2002);
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