Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用
(2R,4R)-trans-Ketoconazole is an isomer of Ketoconazole (K186000). Ketoconazole inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. It has antimetastatic and antineoplastic activity and is an orally active 5-lipoxygenase and thromboxane synthase inhibitor.
参考文献
Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)
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