1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one is an intermediate in synthesizing GFT-505 (G368870), which is a┬аdual┬аPPARa/╬┤ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.
参考文献
Carious, B., et al.:В Diabetes Care 36, 2923 (2013);В Carious, B., et al.:В Diabetes Care 34, 2008 (2011);
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