Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用
3-Methyl-3-phenyl-2-oxiranecarboxylic Acid Methyl Ester is an intermediate in the synthesis of 4,6-Dimethoxy-b-methyl-3-phenoxy Ambrisentan (Mixture of Diastereomers) (D460510). 4,6-Dimethoxy-b-methyl-3-phenoxy Ambrisentan (Mixture of Diastereomers) is a related compound of Ambrisentan (A575860) used as endothelin receptor antagonist in treating cancer.
参考文献
Nelson, J., et al.: Nature Med., 1, 944 (1995); Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996)
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