Building Blocks; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用
Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.
参考文献
Kjell, D.P., et al.: Org. Proc. Res. Development., 9, 738 (2005); Taylor, E. C., et al.: J. Org. Chem., 66, 3726 (2001);
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