In recent years, an increased interest in oxadiazoles has emerged in drug discovery research, as well as in other areas of academia [1]. Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms[2]. Among the stable isomers, the 1,3,4- and the 1,2,4-isomers have received considerable attention, in particular, because of their inherent role as bioisosteres for carboxylic acid derivatives. Accordingly, the literature is rich in examples of 1,3,4-oxadiazole-containing structures displaying antimicrobial, anticonvulsant, anti-inflammatory, antitumor, antiviral activity etc.[1, 3-7].
[1] Advanced Synthesis & Catalysis (2014), 356(14-15), 3074-3082.
[2] Journal of Medicinal Chemistry (2012), 55(5), 1817-1830.
[3] Journal of Medicinal Chemistry (2018), 61(11), 4993-5008.
[4] Journal of Medicinal Chemistry (2020), 63(23), 14989-15012.
[5] Journal of Medicinal Chemistry (2019), 62(22), 10221-10244.
[6] European Journal of Medicinal Chemistry (2020), 206, 112672.
[7] European Journal of Medicinal Chemistry (2017), 138, 140-151.
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