Isoxazole moiety is an important five-membered heterocycle containing one oxygen atom with nitrogen[1]. Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for chemists and pharmacologists from research groups all over the world [2]. Isoxazole-based heterocycles are most bountiful among the biologically active compounds [1], and thanks to their usually low cytotoxicity, isoxazole derivatives are popular scaffolds for the development of new agents with variable biological activities, such as antimicrobial, antiviral, anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or anti-diabetic properties[2-7].
[1] European Journal of Medicinal Chemistry (2021), 221, 113511.
[2] European Journal of Medicinal Chemistry (2017), 137, 292-309.
[3] Journal of Medicinal Chemistry (2021), DOI: 10.1021/acs.jmedchem.1c00475.
[4] Journal of Medicinal Chemistry (2016), 59(6), 2820-2840.
[5] Journal of Medicinal Chemistry (2017), 60(12), 5086-5098.
[6] Journal of Medicinal Chemistry (2019), 62(17), 8284-8310.
[7] Journal of Medicinal Chemistry (2019), 62(18), 8557-8577.
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