Nucleosides play a key role in biology processes, involving in the retention, replication and transcription of gene information[1]. Nucleoside analogues can be used as a nucleic acid metabolism inhibitor to interfere with virus reproduction and tumor cell growth, showing good antiviral and anti-tumor effects. Nucleoside drugs are mainly divided into enzyme inhibitors and DNA chain terminators. They are recognized by specific proteins on the cell membrane and then transferred to the cells, which can be monophosphorylated, diphosphorylated and then triphosphorylated by the kinases, including thymidine kinases (TKs), adenosine kinase (AK), deoxycytidine kinase (dCK), and deoxyguanosine kinase (dGK)[2-7].
[1] Journal of Biological Chemistry (2021), 297(1), 100867.
[2] CN112778310 A 2021-05-11.
[3] Journal of Medicinal Chemistry (2021), 64, 7, 4206-4238.
[4] Journal of Medicinal Chemistry (2021), 64, 7, 3911-3939.
[5] Journal of Medicinal Chemistry (2020), 63, 8, 4334-4348.
[6] Journal of Medicinal Chemistry (2019), 62, 19, 8847-8865.
[7] European Journal of Medicinal Chemistry 214 (2021) 113233.
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