最新药物分子砌块-2021/12 2021/12/04 14:12:34

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Pyrazoles are a kind of important five-member nitrogen heterocyclic compounds, which have important application value in medicine[1]. Pyrazole heterocyclic ring represents an important building block in organic chemistry, bioorganic and medicinal chemistry[2]. It gained a lot of attention for its therapeutic potential as a backbone in advanced medical applications and ease of preparation. Pyrazole containing scaffolds displayed broad range of biological activities, such as anti-inflammatory, anticonvulsant, anticancer, antiviral, antidepressant, antipyretic, and selective enzyme inhibition[3-9] .

A series of medicinal products containing pyrazoles has been firmly incorporated in medical practice
A series of medicinal products containing pyrazole have been firmly
incorporated in medical practice.

[1] Journal of Medicinal Chemistry 2019, 62, 15, 7264-7288.
[2] Journal of Medicinal Chemistry 2019, 62, 22, 10272-10293.
[3] Journal of Medicinal Chemistry 2019, 62, 22, 10305-10320.
[4] Journal of Medicinal Chemistry 2020, 63, 2, 621-637.
[5] Journal of Medicinal Chemistry 2020, 63, 9, 4517-4527.
[6] Journal of Medicinal Chemistry 2021, 64, 4, 1966-1988.
[7] Journal of Medicinal Chemistry 2021, 64, 9, 6037-6058.
[8] European Journal of Medicinal Chemistry 212 (2021) 113134.

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